HOTAS, an acronym of hands on throttle-and-stick, is the concept of placing buttons and switches on the throttle lever and flight control stick in an aircraft's cockpit. By adopting such an arrangement, pilots are capable of performing all vital functions as well as flying the aircraft without having to remove their hands from the controls.

HOTAS was originally applied to military aircraft, starting with the British interceptor aircraft, the English Electric Lightning, in the late 1950s. The concept quickly spread to numerous other aircraft, such as the General Dynamics F-16 Fighting Falcon, Mikoyan MiG-29, and Eurofighter Typhoon. In more modern implementations, it is often combined with several other input systems, such as direct voice input and helmet-mounted display, to further reduce workload upon pilots as well as the need to divide their attention between the primary controls and other systems. Outside of the cockpit, the Ground Control Stations (GCS) used by drone operators have commonly implemented HOTAS principles as well. Outside of the aviation sector, the HOTAS concept has made a noticeable impact upon both the road vehicle and gaming industries.